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J Investig Allergol Clin Immunol ; Vol 28 (3): doi: /jiaci Abstract. Moderate and severe forms of allergic diseases such as atopic dermatitis and asthma are a challenge for clinicians. In these conditions, which severely affect the quality of life of the patient and frequently have associated allergic comorbidities. J Investig Allergol Clin Immunol ; Vol. 21, Suppl. 3: Abstract: H1 antihistamines constitute one of the main references for the treatment of allergic rhinitis. Classically, these . Chronic urticaria has an important impact upon patient quality of life, and no treatment has yet been developed capable of effectively controlling the disease. The most recent guidelines .