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The determination of gluten immunogenic peptides GIP in stool and urine has been developed as a non-invasive, direct, and specific test for GFD monitoring. We herein summarized the current available literature meeting the clinical utility of GIP determination compared to the available tools in use. Wheat prolamins are termed gliadins and glutenins. Prolamins provide food products with special functional properties such as elasticity as well as extensibility and are characterized by high proline and glutamine content, allowing for the more efficiently packing of proteins but also complicating the enzyme-mediated hydrolysis of their tight structures[ 1 ].

Consequently, many of these proteins are insufficiently degraded by gastric and pancreatic enzymes in the gastrointestinal tract. Therefore, after the ingestion of gluten-containing foods, some gluten peptides can enter the intestinal epithelium and trigger an immune response in genetically predisposed individuals suffering from celiac disease CeD [ 2 - 4 ]. Evidence suggests that gluten can cross the intestinal barrier via the transcellular pathway perpetuating intestinal inflammation in the context of gluten intolerance[ 5 , 6 ].

Another three gluten peptides have been shown to trigger high immunogenicity observed in most CeD patients[ 7 ]. Thus, most of the immune response against gluten may be accounted for by a limited group of gluten epitopes[ 7 ]. As a systemic disease, there are intestinal and extraintestinal symptoms that can be presented individually or in combination. In addition, patients may also be completely asymptomatic[ 11 ].

Intestinal presentation of CeD is common in both the pediatric and adult patient population and is characterized by diarrhea, loss of appetite, abdominal distention, bloating, pain, constipation, or weight loss[ 12 , 13 ]. The most common extraintestinal symptoms are iron deficiency anemia, osteopenia or osteoporosis, hypertransaminasemia, neurological afflictions, or changes in reproductive function[ 10 ].

Nevertheless, a relevant proportion of patients present atypical symptoms or remain asymptomatic despite damage to the intestinal mucosa and elevated CeD-specific serum antibodies, which may delay diagnosis or even be undiagnosed[ 14 ]. Following CeD diagnosis, patients must follow a strict, life-long gluten-free diet GFD , the only treatment currently available, which not only reduces disease symptoms but also allows for the healing of the intestinal epithelia and prevents long-term complications[ 15 - 17 ].

However, following a strict GFD is challenging and requires substantial daily effort, hurting the quality of life in addition to psychological problems and fear of involuntary gluten intake, even in patients considering themselves to be strictly adherent[ 15 , 18 - 20 ]. Gluten-free food availability, inadequate food labeling regulations, cost, and safety are the main barriers related to GFD[ 18 , 21 , 22 ].

Therefore, the frequency of voluntary and involuntary transgressions is high. Inadvertent gluten ingestion was suggested to be more frequent than intentional intake, not only when eating out, but also at home[ 28 - 30 ]. Although continuous patient monitoring is expected to improve GFD adherence, there is no consensus on how frequent and which tools to use in the patient follow-up[ 32 - 35 ].

All available guidelines recommended clinical and dietary evaluation as well as serology tests at least once a year or every two years to confirm the GFD adherence in addition to detecting possible complications[ 14 ]. However, monitoring approaches have not been comprehensively assessed with a clear lack of a gold standard for comparisons[ 36 - 38 ]. Thus, various questions often arise among caregivers and patients regarding the best approach for detecting gluten exposure. GFD follow-up through the detection of excreted GIP has the benefits of being non-invasive, objective, and specific, highlighting its potential as a complementary technique for monitoring CeD treatment[ 8 , 9 ].

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A 1/38 Bethune Place, Newnham: Rent $ in Aug Sold $, in Feb Unit: Land size: sqm: Building size: sqm: Agent: Living Here Launceston: Distance: km to CBD: More Photos: Map: Property Description: Enjoy the experience, Living Here This property is located at the end of a quiet street in Newnham. This 3 bedroom with 2 bathroom & 1 carspaces/garages is located at 14 Bethune Place, Newnham TAS This property is now withdrawn. View it or get in touch with the real estate agency. Homehound. Homehound. 14 Bethune Place, Newnham TAS As Good As New! Neg. Over $, 1/38 Bethune Place, Newnham TAS Rent $/week on Sep Distance To CBD: km Nearby Sold Price Nearby Rent Price.